Discussant\u27s response to the new AICPA Audit Commission -- Will the real questions please stand up?

https://egrove.olemiss.edu/dl_proceedings/1062/thumbnail.jp

Audit theory paradigms

https://egrove.olemiss.edu/dl_proceedings/1035/thumbnail.jp

Methane Reducing Technologies: Efficiency, Effectiveness, and Reception

This topic brings together many of the areas that I have studied throughout my education at the University of Colorado Boulder, where I studied Environmental Studies and Economics. I was originally interested in pursuing technology and policy options for methane reductions because methane is a potent greenhouse gas that is often overlooked in the decision-making process. The issues surrounding methane emissions in the United States represents a tremendous inefficiency in our society. There exist solutions that bring developed innovations together to benefit industry, the economy, the environment, and human health. These innovations allow our current technologies, systems, and choices to become more efficient and cost-effective

Unbiased estimation in seamless phase II/III trials with unequal treatment effect variances and hypothesis-driven selection rules.

Seamless phase II/III clinical trials offer an efficient way to select an experimental treatment and perform confirmatory analysis within a single trial. However, combining the data from both stages in the final analysis can induce bias into the estimates of treatment effects. Methods for bias adjustment developed thus far have made restrictive assumptions about the design and selection rules followed. In order to address these shortcomings, we apply recent methodological advances to derive the uniformly minimum variance conditionally unbiased estimator for two-stage seamless phase II/III trials. Our framework allows for the precision of the treatment arm estimates to take arbitrary values, can be utilised for all treatments that are taken forward to phase III and is applicable when the decision to select or drop treatment arms is driven by a multiplicity-adjusted hypothesis testing procedure. © 2016 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd

The open reading frame 5A of foxtail mosaic virus is expressed in vivo and is dispensable for systemic infection

Infectious transcripts were successfully derived from full-length cDNA clones of foxtail mosaic potexvirus (FoMV). Full-length clones were constructed by RT-PCR whereby 50 and 30 genomic segments of 2.7 and 3.4 kb, respectively, were ligated into Bluescript II KS. The in vitro RNA transcripts were infectious to moncotyledonous (barley) and dicotyledonous (Chenopodium amaranticolor) plant species. Individual mutation studies on clones of each of the five major ORFs confirmed predicted gene function for the polymerase, TGB (triple gene block), and coat protein (CP) genes. Protoplast studies on expression of a unique open reading frame, ORF 5A, which initiates 143 nts upstream of the CP before it “reads through” the CP, revealed that the 5A protein was produced in vivo. Mutation analysis of the 5A ORF indicated, however, that it was not required for either replication or for productive infection of plants. However, the nucleic acid sequences encoding the extended CP segment were shown to be important for CP expression. Additional mutations in 5A had no effect on FoMV replication in protoplasts but rendered the virus noninfectious to plants. A correlation with diminished CP production from both mutant clones implies that synthesis of subgenomic CP mRNA was compromised, and this limited systemic infection